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Pathophysiology - acute Vs. chronic

 

Acute

Chronic

Cardiovascular

Hypotension
Tachycardia

mildly hyperdynamic

Respiratory

ARDS

Diapragmatic splinting
Shunt

Renal

Renal failure (paracetamol)

Na+ retention
Effect of diuretics
Hepato-renal syndrome

GIT

Jaundice
Pancreatitis (paracetamol)

Jaundice
Ascites
Varices

Neurology

Encephalopathy
Intracranial hypertension


Encephalopathy

Metabolic

Hypoglycaemia
Coagulopathy
Hyponatraemia
Gram positive / fungal infections

Coagulopathy
Hyponatraemia

Table 3. Summary of pathophysiology of hepatic failure.

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