Acute Kidney Injury Part 1:
The RIFLE Classification
- The RIFLE classification is the consensus classification for acute kidney injury.
- RIFLE stands for: Risk, Injury, Failure, Loss and End stage kidney disease (ESKD).
- It is designed to encapsulate the varying degrees of kidney dysfunction (from mild to more severe) and it's criteria are presented in table 1:
Table 1: The RIFLE classification
|Class||Glomerular filtration rate criteria||Urine output criteria|
Increased serum creatinine 1.5 x baseline, or
GFR decreased by > 25%
Urine output < 0.5ml/kg/hr for 6 hours
Increased serum creatinine 2 x baseline, or
GFR decreased by > 50%
Urine output < 0.5 ml/kg/hr for 12 hours
Increased serum creatinine 3 x baseline, or
a serum creatinine > 350micromol/l, or
GFR decreased by > 75%
Urine output < 0.3 ml/kg/hr for 24 hours, or
Anuria for 12 hours
|Loss||Complete loss of kidney function for > 4 weeks|
|ESKD||Persistent loss of kidney function with the requirement for ongoing dialysis for more than 3 months|
(GFR = Glomerular Filtration rate)
The criteria (serum creatinine or urine output) that result in the worst possible classification
should be used.