Find out what you should do within the first 24 hours and beyond during the ongoing management of sepsis.

Patients with severe sepsis should be managed in an ICU or HDU setting.

Good basic medical care is of paramount importance, as is close attention to infection control and prevention of hospital acquired infection.

Appropriate thromboembolism prophylaxisshould be given balanced with appropriate treatment of any resulting coagulopathy.

Appropriate stress ulcer prophylaxis should be given.

If mechanically ventilated, lung protective ventilation should be instituted to avoid VILI.

Limitation of tidal volumes to 6ml/kg and airway plateau pressures to 30cm H0 is recommended. 

Early enteral nutrition should be commenced once haemodynamic stability is achieved, though caution in those on very high doses of inotropes.

Appropriate glucose control.