In summary, the initial settings that would be reasonable for most patients are:

• FIO₂: 1.0
• PEEP: 5–10 cm H₂O
• Mode: Controlled ventilation
• Inspiratory pressure: 25 cm H₂O or tidal volume 400 ml (adjust to tidal volume of 6 ml/kg ideal body weight)
• I:E ratio: 1:2
• Respiratory rate: 15/min